Featured in this issue is an editorial on insights from the 2025 Conference on Public Health in Africa (CPHIA), which called for strong National Public Health Institutes, interoperable data systems, routine use of advanced surveillance tools, and predictable domestic financing. Also featured are early programmatic results on long-acting injectable Cabotegravir for HIV pre-exposure prophylaxis in Livingstone District, as well as a case investigation of suspected Drug-resistant Tuberculosis in Chongwe District.